| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759787 | Biochemical and Biophysical Research Communications | 2013 | 7 Pages |
Abstract
⺠Lancemaside A inhibited iNOS, COX-2 and proinflammatory cytokines in microglia. ⺠Lancemaside A selectively inhibited LPS-induced JNK phosphorylation. ⺠SP600125 exerts similar anti-inflammatory/antioxidant effects to lancemaside A. ⺠The neuroprotective effects of lancemaside A and SP600125 were demonstrated.
Keywords
PI3KHemeoxygenase-1AP-1iNOSERKCOX-2HO-1JnkNF-κBc-Jun N-terminal kinaseMAPKNeuroinflammationinducible nitric oxide synthaseCyclooxygenase-2nuclear factor-κBphosphoinositide 3-kinaseNeuroprotectionJNK signaling pathwayMicrogliaactivator protein-1mitogen-activated protein kinaseextracellular signal-regulated kinase
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Yeon-Hui Jeong, Ji-Sun Jung, Thi Kim Van Le, Dong-Hyun Kim, Hee-Sun Kim,