| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759789 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠Circadian core protein BMAL1 is modified with an O-linked β-N-acetylglucosamine (O-GlcNAc). ⺠O-GlcNAcylation of BMAL1 stabilizes the protein. ⺠O-GlcNAcylation of BMAL1 enhances its transcriptional activity. ⺠Inhibition of O-GlcNAcylation results in dampened circadian rhythms of clock gene expression.
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Authors
Yan-Tao Ma, Hunjin Luo, Wen-Juan Guan, Hua Zhang, Chongfen Chen, Ziyao Wang, Jia-Da Li,