| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759808 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠LMT-335 is a novel synthetic antioxidant designed as an anti-ischemic agent. ⺠LMT-335 protected neurons from oxygen-glucose deprivation and reoxygenation. ⺠LMT-335 reduced OGD/R-evoked oxidative stress by enhancing astroglial HO-1 proteins. ⺠HO-1 inhibitor SnPP abolished the neuroprotective effect of LMT-335. ⺠Our data propose astroglial HO-1 as a novel therapeutic target for ischemic stroke.
Keywords
AAPHNMDARNSN-methyl-d-aspartateHeme oxygenase-1AstrogliaHO-1heme-oxygenase-1H2DCF-DAORACDPPH1,1-diphenyl-2-picrylhydrazylOGD/RROSSnPPCerebral ischemiaOxidative stressCNScentral nervous systemoxygen radical absorbance capacitylactate dehydrogenaseLDHPropidium iodidetin protoporphyrin IXreactive nitrogen speciesReactive oxygen species
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Authors
Chung Ju, Sumi Song, Minkyoung Kim, Yongseok Choi, Won-Ki Kim,