| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759848 | Biochemical and Biophysical Research Communications | 2013 | 8 Pages |
Abstract
⺠We examined the role of Nox4 on collagen accumulation in vivo and vitro. ⺠TGFβ1-induced collagen accumulation in sponges cotreated with Adv-Nox4ÎNADPH implanted in mice. ⺠Suppressing Nox4 reduced collagen accumulation in vivo. ⺠Inhibiting Nox4 gene expression and ROS release reduced collagen synthesis in vitro. ⺠Nox4 acts as an intermediary effector to facilitate TGFβ-induced collagen synthesis.
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Authors
Elsa C. Chan, Hitesh M. Peshavariya, Guei-Sheung Liu, Fan Jiang, Shiang-Yong Lim, Gregory J. Dusting,