Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-ÎºB and ERK signaling pathways

Article ID	Journal	Published Year	Pages	File Type
10759856	Biochemical and Biophysical Research Communications	2013	6 Pages	PDF

Abstract

âº A natural-derived compound, sanguinarine, suppresses osteoclastic bone resorption. âº Sanguinarine inhibits the RANKL-induced osteoclast formation. âº Sanguinarine impairs the NF-ÎºB and ERK pathways during osteoclastogenesis. âº Sanguinarine have therapeutic value in treating osteoclast-related oral diseases.

Keywords

NF-κB ERK Osteoclast Bone resorption Sanguinarine

Related Topics

Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry

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Sanguinarine inhibits osteoclast formation and bone resorption via suppressing RANKL-induced activation of NF-ÎºB and ERK signaling pathways

Authors

Haowei Li, Zanjing Zhai, Guangwang Liu, Tingting Tang, Zhen Lin, Minghao Zheng, An Qin, Kerong Dai,