| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759872 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠P53 can undergo conformational transitions leading to amyloid formation. ⺠P53 forms soluble oligomers and amyloid fibrils that cannot bind to DNA. ⺠Detection of p53 oligomers and fibrils in human cases of basal cell carcinoma. ⺠P53 amyloid-oligomers promote cell death in basal cell carcinoma. ⺠P53 amyloid formation has a dual role in the pathogenesis of cancer.
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Authors
Cristian A. Lasagna-Reeves, Audra L. Clos, Diana Castillo-Carranza, Urmi Sengupta, Marcos Guerrero-Muñoz, Brent Kelly, Richard Wagner, Rakez Kayed,