Cyclic strain dominates over microtopography in regulating cytoskeletal and focal adhesion remodeling of human mesenchymal stem cells

Article ID	Journal	Published Year	Pages	File Type
10759903	Biochemical and Biophysical Research Communications	2013	7 Pages	PDF

Abstract

âº Physical cues of the microenvironment are proposed to regulate stem cell function. âº Cyclic strain remodels the actin cytoskeletal and focal adhesions. âº Microtopography remodels the actin cytoskeletal and focal adhesions. âº Cyclic strain dominates over microtopography in gene expression. âº External mechanical stimuli regulate the stem niche.

Keywords

PDMS RT-PCR DAPI hMSC MMP13 4′, 6-diamidino-2-phenylindole FLAT Microarray human mesenchymal stem cell Matrix metalloproteinase 13 Migration Micromechanics Real time polymerase chain reaction post Polydimethylsiloxane Adhesion