Angiotensin-(1-7) decreases glycated albumin-induced endothelial interleukin-6 expression via modulation of miR-146a

Article ID	Journal	Published Year	Pages	File Type
10759953	Biochemical and Biophysical Research Communications	2013	7 Pages	PDF

Abstract

âº Glycated albumin increases endothelial IL-6 expression. âº Angiotensin-(1-7) decreases glycated albumin-induced endothelial IL-6 expression. âº Angiotensin-(1-7) modulates endothelial IL-6 expression via miR-146a.

Keywords

NAPDH Nox-4 Ox-LDL phorbol 12-myristate 13-acetate IL-8 LPS IL-6 ACE2 IL-1β MTS GAPDH PMA NADPH oxidase 4 Glycated albumin Angiotensin-converting enzyme 2 Angiotensin-(1–7)HAEC Interleukin-8 interleukin-6 Interleukin-1β miR-146a Enzyme-linked immunosorbent assay ELISA tumor necrosis factor-α human aortic endothelial cell Endothelial cells Age TNF-α Oxidized low-density lipoprotein lipopolysaccharide MicroRNA MiRNA polymerase chain reaction PCR advanced glycation end product glyceraldehyde-3-phosphate dehydrogenase