Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10759973 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠We construct and purify a fusion protein VEGF-SEA. ⺠VEGF-SEA strongly repressed the growth of murine solid sarcoma 180 (S180) tumors. ⺠T cells driven by VEGF-SEA were accumulated around tumor cells bearing VEGFR by mice image model. ⺠VEGF-SEA can serve as a tumor targeting agent and sequester CTLs into the tumor site. ⺠The induced CTLs could release the cytokines, perforins and granzyme B to kill the tumor cells.
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Authors
Qingwen Sun, Songmin Jiang, Baohui Han, Tongwen Sun, Zhengnan Li, Lina Zhao, Qiang Gao, Jialin Sun,