| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10759975 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Annexin-1 is involved in a wide range biological function and is an important anti-inflammatory mediator. ⺠Green tea induces Annexin-1 and inhibits COX-2 expression and PGE2 production in NSCLC. ⺠Data from siRNA experiment indicates that the anti-inflammatory activity is mediated by the up-regulation of Annexin-1. ⺠However, differential pattern of inhibitory effects of Annexin-1 on cPLA2 expression was observed among various cell types. ⺠Our study may provide a new mechanism of green tea on the prevention of lung cancer.
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Authors
Qing-Yi Lu, Yusheng Jin, Jenny T. Mao, Zuo-Feng Zhang, David Heber, Steven M. Dubinett, Jianyu Rao,