| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760013 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠A panel of reference antiviral molecules was screened against norovirus. ⺠2â²-C-methylcytidine (2CMC) was identified as an inhibitor of the replication of (murine) norovirus. ⺠2CMC inhibits virus-induced CPE formation, the production of infectious viruses and viral RNA synthesis. ⺠The antiviral effect coincides with the onset of viral RNA synthesis, suggesting the viral polymerase as target. ⺠When combined with ribavirin a marked antagonistic activity is observed.
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Authors
J. Rocha-Pereira, D. Jochmans, K. Dallmeier, P. Leyssen, R. Cunha, I. Costa, M.S.J. Nascimento, J. Neyts,