| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760068 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠Na+ coupled phosphate carrier NaPiIIa (SLC34A1) is upregulated by janus kinase JAK2. ⺠The effect is mimicked by active JAK2V617F, but not inactive JAK2K882E. ⺠NaPiIIa activity is decreased by JAK2 inhibitor AG490. ⺠JAK2V617F increases NaPiIIa protein abundance in the cell membrane. ⺠JAK2 modifies carrier insertion into rather than carrier retrieval from cell membrane.
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Authors
Manzar Shojaiefard, Zohreh Hosseinzadeh, Tatsiana Pakladok, Shefalee K. Bhavsar, Florian Lang,