Article ID Journal Published Year Pages File Type
10760165 Biochemical and Biophysical Research Communications 2013 6 Pages PDF
Abstract
► MK886 sensitizes glioma cells to TRAIL-mediated apoptosis via upregulation of DR5. ► Upregulation of DR5 induced by MK886 is regulated by p38 MAPK. ► Knockdown of p38 MAPK blocks DR5 upregulation and TRAIL-induced apoptosis. ► MK886-induced TRAIL sensitization is independent of ROS.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Lipoxygenase inhibitor MK886 potentiates TRAIL-induced apoptosis through CHOP- and p38 MAPK-mediated up-regulation of death receptor 5 in malignant glioma
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