Insulin suppression of apolipoprotein B in McArdle RH7777 cells involves increased sortilin 1 interaction and lysosomal targeting

Article ID	Journal	Published Year	Pages	File Type
10760171	Biochemical and Biophysical Research Communications	2013	6 Pages	PDF

Abstract

âº Insulin suppresses VLDL B100 secretion via PI3K in McArdle RH7777 rat hepatoma cells. âº Insulin enhances sortilin 1-B100 interaction. âº Inhibition of lysosomal degradation by BafA1 blocks insulin suppression of VLDL B100. âº BafA1 inhibition reveals increased insulin-dependent sortilin 1-B100 interaction. âº Sortilin 1-B100 interaction likely mediates insulin-dependent B100 degradation.

Keywords

PI3K ERAD VLDL BAFA1 B100 apo B Apolipoprotein B insulin bafilomycin A1 Endoplasmic reticulum associated degradation lipoprotein secretion phosphatidylinositide 3-kinase very low density lipoprotein