Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10760174 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠Infusion of BAIB increased dimethylarginine plasma levels in mice. ⺠Infusion of BAIB decreased plasma levels of AGXT2-derived ADMA metabolites. ⺠Expression of Agxt2 was not affected by BAIB infusion. ⺠First in vivo evidence that endogenous Agxt2 regulates ADMA and SDMA plasma levels. ⺠Heritable hyper-BAIB-uria may be associated with impaired methylarginine metabolism.
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Authors
Anja Kittel, Renke Maas, Jörg König, Maren Mieth, Norbert Weiss, Natalia Jarzebska, Bernd Hohenstein, Jens Martens-Lobenhoffer, Stefanie M. Bode-Böger, Roman N. Rodionov,