| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760175 | Biochemical and Biophysical Research Communications | 2013 | 5 Pages |
Abstract
⺠Simvastatin inhibits the core promoter of the TXNRD1 gene in HepG2 cells. ⺠Simvastatin inhibits the mRNA levels of TrxR1 and the enzyme activity in HepG2 cells. ⺠Atorvastatin and fluvastatin do not influence the TrxR1 mRNA levels or TXNRD1 promotor activity. ⺠These findings add novel insight in the mechanism behind anticarcinogenic effects of statins.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Lena Ekström, Maria Johansson, Katalin Monostory, Anna-Klara Rundlöf, Elias S.J. Arnér, Linda Björkhem-Bergman,