Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10760251 | Biochemical and Biophysical Research Communications | 2013 | 7 Pages |
Abstract
⺠Natural and synthetic inhibitors of human phosphomevalonate kinase identified. ⺠Virtual screening yielded a hit rate of 15%, with inhibitor Kd's of 10-60 μM. ⺠NMR studies indicate significant protein conformational changes upon binding.
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Authors
Pornthip Boonsri, Terrence S. Neumann, Andrew L. Olson, Sheng Cai, Timothy J. Herdendorf, Henry M. Miziorko, Supa Hannongbua, Daniel S. Sem,