| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760263 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠Metformin inhibits cancer cell growth but the mechanism(s) are not understood. ⺠We show that the potency of metformin is sharply dependent on glucose in the medium. ⺠AMPK activation was enhanced in cancer cells incubated in physiological glucose. ⺠Reciprocally, metformin potently inhibited mTORC1, DNA synthesis and proliferation. ⺠Metformin, at low concentrations, inhibited DNA synthesis through AMPK.
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Authors
James Sinnett-Smith, Krisztina Kisfalvi, Robert Kui, Enrique Rozengurt,