| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760277 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠HDAC6 is a multifunctional protein that is localized in cytoplasmic inclusions in α-synucleinopathy. ⺠We investigated whether brain level and activity of HDAC6 are altered in the patients with neurodegenerative dementia. ⺠Expression levels of HDAC6 were induced in MSA and FTLD-TDP relative to controls. ⺠The activity did not parallel the induced level of HDAC6. ⺠HDAC6 activity may be affected in the brains with MSA and FTLD-TDP.
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Authors
Saori Odagiri, Kunikazu Tanji, Fumiaki Mori, Yasuo Miki, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi,