| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760280 | Biochemical and Biophysical Research Communications | 2013 | 7 Pages |
Abstract
⺠Pipernonaline induces sub-G1 accumulation and G1/S phase transition of PC-3 cells. ⺠Pipernonaline triggers caspase-dependent apoptosis by elevating ROS production. ⺠ROS cause its downstream events, Ca2+i increase and mitochondrial depolarization. ⺠ROS, Ca2+i and mitochondrial function are reversed by antioxidant N-acetylcysteine. ⺠This is the first report of pipernonaline toward the anti-prostate cancer activity.
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Authors
Wan Lee, Kwang-Youn Kim, Sun-Nyoung Yu, Sang-Hun Kim, Sung-Sik Chun, Jae-Hoon Ji, Hak-Sun Yu, Soon-Cheol Ahn,