| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760285 | Biochemical and Biophysical Research Communications | 2013 | 4 Pages |
Abstract
⺠The NLRP3 inflammasome displayed decreased levels in human ischemic heart. ⺠We observed reduced mRNA levels of MEFV in ischemic heart tissue. ⺠Genetic analysis showed mutations in NLRP3 and MEFV only in ischemic heart tissue. ⺠Low expression of NLRP3 and MEFV may have a role in a defective immune response. ⺠Defects in the inflammasome may be involved in promoting ischemic heart disease.
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Authors
Cecilia Hermansson, Annika Lundqvist, Carina Wasslavik, Lars Palmqvist, Anders Jeppsson, Lillemor Mattsson Hultén,