| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760318 | Biochemical and Biophysical Research Communications | 2013 | 4 Pages |
Abstract
⺠Cathepsin K expression is enhanced by LPS stimulation via a TLR-4 pathway. ⺠HA inhibits LPS-induced expression of cathepsin K and MMP-1. ⺠Inhibition of cathepsin K expression depends on CD44 but not ICAM-1 interaction. ⺠Inhibition of MMP-1 expression is mediated by both CD44 and ICAM-1 interaction. ⺠Intra-articular HA administration has protective effects, useful in RA treatment.
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Authors
Shinya Hirabara, Toshihisa Kojima, Nobunori Takahashi, Masahiro Hanabayashi, Naoki Ishiguro,