Solution structure and dynamics of C-terminal regulatory domain of Vibrio vulnificus extracellular metalloprotease

Article ID	Journal	Published Year	Pages	File Type
10760325	Biochemical and Biophysical Research Communications	2013	6 Pages	PDF

Abstract

âº We have determined solution structures of vEP C-terminal regulatory domain. âº vEP C-ter100 has a compact Î²-barrel structure with eight anti-parallel Î²-strands. âº Solution structure of vEP C-ter100 shares its molecular topology with that of the collagen-binding domain of collagenase. âº Residues in the Î²3 region of vEP C-ter100 might be important in putative ligand/receptor binding. âº vEP C-ter100 interacts strongly with iron ion.

Keywords

C-terminal propeptide HCCH Three-dimensional NOESY PDB TOCSY VEP nuclear magnetic resonance Nuclear Overhauser Effect SpectroscopY NMR Solution structure septicemia NMR spectroscopy total correlated spectroscopy Wound infection Fluorescence Protein Data Bank