| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760334 | Biochemical and Biophysical Research Communications | 2013 | 31 Pages |
Abstract
⺠WT LRRK2 is degraded by WT LRRK2/I2020T LRRK2 (WT/IT)-heterodimer formation. ⺠Anti-apoptotic protectivity of LRRK2 is impaired by WT/IT-heterodimer formation. ⺠Akt1 phosphorylation activity of LRRK2 is impaired by WT/IT-heterodimer formation. ⺠I2020T mutation causes dominant-negative effect on neurodegeneration.
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Authors
Etsuro Ohta, Fumitaka Kawakami, Makoto Kubo, Fumiya Obata,