| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760418 | Biochemical and Biophysical Research Communications | 2013 | 5 Pages |
Abstract
⺠We investigate the role of miR-7-5p in melanoma metastasis. ⺠miR-7-5p inhibits melanoma cell migration and invasion in vitro. ⺠IRS-2 is a target of miR-7-5p and promotes melanoma migration and Akt signaling. ⺠Therapeutic upregulation of miR-7-5p may be of benefit in melanoma treatment.
Keywords
RT-qPCRv-raf-1 murine leukemia viral oncogene homolog 1IRS-2CEBv-raf murine sarcoma viral oncogene homolog B1BRAFPAK1IRS-1FAKGAPDHPI3KEGFRp21-activated kinase 1Aktinsulin receptor substrate-1InvasionMelanomaRaf1Insulin receptor substrate-2SignalingPhosphatidylinositol 3-kinaseMetastasisMigrationMicroRNAMiRNAprotein kinase Bfocal adhesion kinaseglyceraldehyde 3-phosphate dehydrogenaseEpidermal growth factor receptor
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Authors
Keith M. Giles, Rikki A.M. Brown, Michael R. Epis, Felicity C. Kalinowski, Peter J. Leedman,