| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760513 | Biochemical and Biophysical Research Communications | 2013 | 6 Pages |
Abstract
⺠Micro-RNA 126 is an endothelial-specific pro-angiogenic miR encoded by the Egfl7 gene. ⺠Expression of miR-126 was activated in cardiac myocytes by hypoxia and HDAC inhibition. ⺠Hypoxia and TSA activated survival kinases ERK1/2 and Akt in a miR-126-dependent manner. ⺠Mir-RNA-126 plays a pro-survival role in hypoxic cardiac myocytes. ⺠Mir-126 activation may account in part for the cardioprotective properties of HDAC inhibitors.
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Authors
Huaping Shi, Lei Chen, Huilan Wang, Shoukang Zhu, Chunming Dong, Keith A. Webster, Jianqin Wei,