| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760548 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠HCV core protein inhibits IRF-3 dimerization/phosphorylation, and IFN-β induction. ⺠The N-terminal region of the core protein inhibits the IFN signaling cascades. ⺠The N-terminal region, basic amino acid region 1 interferes with IRF-3 activation. ⺠DDX3 may be the core protein target for inhibiting IRF-3 activation. ⺠Rescue of the IRF-3 pathway impairment may be effective against HCV infection.
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Authors
Kazuaki Inoue, Kyoko Tsukiyama-Kohara, Chiho Matsuda, Mitsutoshi Yoneyama, Takashi Fujita, Shusuke Kuge, Makoto Yoshiba, Michinori Kohara,