| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760588 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Mutations of the HNF1α gene cause a form of monogenic diabetes. ⺠We established the MIN6 β-cell line that stably expressed HNF1α-specific shRNA. ⺠Expression of HGF activator mRNA was decreased in the knockdown cell line. ⺠We identified that HGF activator is a direct HNF1α target gene in β-cells. ⺠HNF1α might regulate β-cell function by modulating HGF activator expression.
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Authors
Tsuyoshi Ohki, Yoshifumi Sato, Tatsuya Yoshizawa, Ken-ichi Yamamura, Kentaro Yamada, Kazuya Yamagata,