Article ID Journal Published Year Pages File Type
10760595 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► Aβ treatment induces BACE1 expression via calcium-related signaling in astrocytes. ► NFAT4 modulates astrocytic BACE1 level via direct promoter binding. ► Aβ-elicited BACE1 expression is mediated by calcium influx. ► BACE1 is expressed in calcineurin-positive astrocytes surrounding amyloid plaques.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Aβ-induced Ca2+ influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals
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