| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760608 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠The structural basis of the Kallmann syndrome is elucidated. ⺠Kallmann syndrome mutation (A168S) induces a subtle conformational change(s). ⺠Structural interactions mediated by beta-sheet G are most perturbed. ⺠Ligand (FGF)-receptor interaction(s) is completely abolished by Kallmann mutation. ⺠Kallmann mutation directly affects the FGF signaling process.
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Authors
Ryan D. Thurman, Karuppanan Muthusamy Kathir, Dakshinamurthy Rajalingam, Thallapuranam K. Suresh Kumar,