Tumor cells can evade dependence on autophagy through adaptation

Article ID	Journal	Published Year	Pages	File Type
10760615	Biochemical and Biophysical Research Communications	2012	5 Pages	PDF

Abstract

âº Autophagy under actual or chronic inhibition had different impact on cell survival. âº Long term suppression of autophagy may not be useful for cancer therapy. âº Tumors arising with autophagy deficiency likely adapt to new survival mechanisms.

Keywords

PBS ATG5 DMEM PVDF LC3 MEF Dulbecco’s modified Eagle medium SDS–PAGE Autophagy Sodium dodecyl sulfate polyacrylamide gel electrophoresis RIPA buffer radioimmunoprecipitation buffer Anticancer therapy polyvinylidene difluoride Phosphate buffered saline phosphatidylethanolamine murine embryonic fibroblasts Proteasome inhibitors microtubule-associated protein 1 light chain 3