| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760623 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Senile plaque, which is observed on a neuronal membrane in patients of Alzheimer's disease, is a spherulitic fibrillar aggregate. ⺠Fragmented fibrils could interact with anionic liposomes to form spherulitic fibrillar aggregates. ⺠Anionic liposomes enable a reproducible modeling of a senile plaque of a protein from Alzheimer's disease. ⺠The fragmentation of fibrils is a crucial for a formation of senile plaques.
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Authors
Toshinori Shimanouchi, Naoya Shimauchi, Ryo Ohnishi, Nachi Kitaura, Hisashi Yagi, Yuji Goto, Hiroshi Umakoshi, Ryoichi Kuboi,