Article ID Journal Published Year Pages File Type
10760631 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► Melanoregulin-GFP targets extensively to the limiting membrane of the melanosome. ► Endogenous melanoregulin also targets extensively to the melanosome. ► Melanoregulin targeting to melanosomes and lysosomes requires N-terminal cysteines. ► SDM, metabolic labeling and inhibitors show that melanoregulin is palmitoylated on these cysteines. ► FRAP shows that melanoregulin is stably targeted to the melanosome membrane.
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