Article ID Journal Published Year Pages File Type
10760640 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► Cigarette smoking impair macrophage bacterial phagocytosis but mechanisms unclear. ► Cigarette smoke (CS) exposure increase oxidized phospholipids (Ox-PLs) in mice lungs. ► Instillation of Ox-PLs impair bacterial clearance in mice lungs. ► EO6 mAb prevents Ox-PLs induced inhibition of macrophage bacterial phagocytosis. ► Ox-PLs in lungs of CS-exposed mice impair macrophage bacterial phagocytosis.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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Oxidized phospholipids impair pulmonary antibacterial defenses: Evidence in mice exposed to cigarette smoke
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