| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760664 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Direct role of Bcl-2 protein interactions in cell proliferation is not clear. ⺠Designed Bcl-xL mutants show opposite effects on apoptosis and proliferation. ⺠Disrupting Bcl-xL:Bim interaction increased apoptosis in pancreatic cancer. ⺠Disrupting Bcl-xL:Bim interaction decreased proliferation in pancreatic cancer. ⺠Bcl-xL:Bim interaction can control both apoptosis and proliferation.
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Authors
Ravinder Abrol, Mouad Edderkaoui, William A. III, Stephen J. Pandol,