| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760696 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Full-length 21.5-kDa MBP isoform is translocated to the nucleus. ⺠We hypothesized that the exon-II-encoded sequence contained the NLS. ⺠We mutated this sequence in RFP-tagged constructs and transfected N19-cells. ⺠Abolition of two key positively-charged residues resulted in loss of nuclear-trafficking. ⺠The 21.5-kDa isoform of classic MBP contains a non-traditional PY-NLS.
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Authors
Graham S.T. Smith, Lauren V. Seymour, Joan M. Boggs, George Harauz,