Article ID Journal Published Year Pages File Type
10760700 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► β-Catenin expression were markedly down-regulated by CTNNB1 shRNA. ► CTNNB1 shRNA could inhibit the proliferation of RPMI8226 cells. ► Significantly profound apoptotic cell death in CTNNB1 shRNA cells. ► In vivo, CTNNB1 silence led to a growth inhibition of myeloma growth. ► c-myc and β-catenin in the expression cells of cleaved caspase-3 were increased.
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