| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760706 | Biochemical and Biophysical Research Communications | 2012 | 4 Pages |
Abstract
⺠SIRT1 gene promoter was analyzed in sporadic PD patients and ethic-matched controls. ⺠Three novel heterozygous variants within SIRT1 gene promoter were identified in PD cases. ⺠Five SNPs were found in PD patients and controls with similar distributions. ⺠One novel heterozygous variant was only identified in healthy control. ⺠The variants may change SIRT1 levels, contributing to the PD onset as a risk factor.
Keywords
Sir2UCHL-1Leucine-rich repeat kinase 1hypermethylated in cancer 1damage-regulated autophagy modulatorLRRK1PTEN-induced kinase 1PARP-2DRAMPGC1αCREBSNCADJ-1Sirt1PINK1ATGLC3GBANFκBPPARsHIC1Parkinson’s diseasesilent information regulator 2nuclear factor κBFoxOSequence variantmicrotubule-associated protein 1 light chain 3 alphacAMP response element-binding proteinPromoterautophagy-related genesPeroxisome proliferator-activated receptors
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Authors
Aimei Zhang, Hongen Wang, Xianyun Qin, Shuchao Pang, Bo Yan,