| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760784 | Biochemical and Biophysical Research Communications | 2012 | 5 Pages |
Abstract
⺠Acetaldehyde-derived DNA adducts may play a crucial role in carcinogenesis. ⺠The stability of a major DNA adduct N2-ethylidene-2â²-deoxyguanosine is not known. ⺠DNA adduct was analyzed by liquid chromatography-tandem mass spectrometry. ⺠The half-life of DNA adducts was estimated as 35 h in vitro in HL60 cells. ⺠Acetaldehyde exposure from daily alcohol drinking may cause DNA damage.
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Authors
Kimiko Hori, Shin'ichi Miyamoto, Yoshiyuki Yukawa, Manabu Muto, Tsutomu Chiba, Tomonari Matsuda,