Article ID Journal Published Year Pages File Type
10760808 Biochemical and Biophysical Research Communications 2012 6 Pages PDF
Abstract
► We examine neuron dendrite development in Vps18 conditional knockout mice. ► Lysosome degradative function is required for Purkinje cell dendrite development. ► Lox is degraded by lysosome. ► Lysosome regulates Purkinje cell dendrite development through degrading Lox.
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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Vps18 deficiency inhibits dendritogenesis in Purkinje cells by blocking the lysosomal degradation of Lysyl Oxidase
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