| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760818 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠A novel FAK inhibitor TAE226 suppressed FAK activity in HCT116 colon cancer cells. ⺠TAE226 suppressed proliferation and migration, with a modest effect on adhesion. ⺠Silencing of FAK by siRNA made no obvious difference on cancer cell attachment. ⺠TAE226 treatment suppressed the progression of peritoneal dissemination. ⺠Oral administration of TAE226 prolonged the survival of tumor-bearing mice.
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Authors
Hui-fang Hao, Munenori Takaoka, Xiao-hong Bao, Zhi-gang Wang, Yasuko Tomono, Kazufumi Sakurama, Toshiaki Ohara, Takuya Fukazawa, Tomoki Yamatsuji, Toshiyoshi Fujiwara, Yoshio Naomoto,