| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760819 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Smad6 is expressed in human CD34+ cord blood hematopoietic stem cells (HSCs). ⺠HSC-specific expression of Smad6 does not regulate stemness. ⺠Smad6 prevents erythropoiesis in HSCs. ⺠Smad6 represses the genes essential for erythropoiesis, such as KLF1 and GATA-2.
Keywords
burst-forming unit-erythroidBFU-ECFU-GM7-AADCFU-EHSCsGPAco-SMADSCFEYFP7-amino-actinomycin DGM-CSFTβRIR-SmadsBMP type I receptorBMPRII-SmadEPOTGF-βTGF-β type I receptorGFPGATA binding proteincolony-forming unit-erythroidBMPsErythropoiesisSmad6ALKGATAerythropoietininterleukintransforming growth factor-βhematopoietic stem cellsreceptor-regulated Smadsgranulocyte colony-stimulating factorStem Cell FactorG-CSFgranulocyte macrophage colony-stimulating factorBMPyellow fluorescent proteingreen fluorescent proteinbone morphogenetic proteinsPropidium iodideactivin receptor-like kinaseGlycophorin A
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Authors
Young-Ju Kang, Ji-woong Shin, Jeong-Hwan Yoon, Il-Hwan Oh, Soon-Pyo Lee, Suk-Young Kim, Seok Hee Park, Mizuko Mamura,