| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760839 | Biochemical and Biophysical Research Communications | 2012 | 8 Pages |
Abstract
⺠Titers of ANA and anti-dsDNA antibodies were higher in ApoEâ/â than C57B6/L mice. ⺠Spleen was greater and splenocyte apoptosis lower in ApoEâ/â than B6 mice. ⺠Level of TLR4 was lower in spleen tissue of ApoEâ/â than B6 mice. ⺠The TLR4 pathway may participate in maintaining the balance of splenocyte apoptosis. ⺠The TLR4 pathway may participate in antibody production in spleen tissue.
Keywords
MYD88anti-double-stranded DNAApolipoprotein E knockout miceIRF3TLR4TLRp38ApoE−/−anti-nuclear antibodyapolipoprotein E knockoutAutoantibodySplenomegalyANABaxTUNELToll-like receptorApoptosisanti-dsDNAmyeloid differentiation factor 88Interferon regulatory factor 3Bcl-2-associated X proteinp38 mitogen-activated protein kinase
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Authors
Yuehai Wang, Ziyang Huang, Huixia Lu, Huili Lin, Zhenhua Wang, Xiaoqing Chen, Qiufang Ouyang, Mengxiong Tang, Panpan Hao, Jingqin Ni, Dongming Xu, Mingxiang Zhang, Qunye Zhang, Ling Lin, Yun Zhang,