| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760843 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠Novel combination therapy using withaferin A (WFA) and cisplatin. ⺠Combination of WFA with cisplatin elicits synergistic cytotoxic effects. ⺠Combination of WFA with cisplatin significantly reduces the cisplatin dosage requirement. ⺠WFA induces ROS generation, whereas cisplatin induces DNA damage in combination treatment. ⺠Lower dose of cisplatin in combination therapy will minimize/eliminate side effects of cisplatin.
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Authors
Sham S. Kakar, Venkatakrishna R. Jala, Miranda Y. Fong,