| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760885 | Biochemical and Biophysical Research Communications | 2012 | 7 Pages |
Abstract
⺠We addressed how LPS regulates blood-brain barrier permeability by disrupting the tight junction. ⺠PKC (a, β, ζ) and RhoA invovled, but PI3 K and tyrosine kinase not involved in the regulatory process. ⺠PKC-a and PKC-ζ, but not PKC-β interacted with RhoA in Bend.3 cells stimulated by LPS. ⺠PKC-a and PKC-ζ separately acted as the upstream and downstream molecule for Rho. ⺠It may play a role in understanding the mechanism of meningeal inflammation.
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Authors
Fang He, Fei Yin, Ahmed Omran, Li-fen Yang, Qiu-lian Xiang, Jing Peng,