Article ID Journal Published Year Pages File Type
10760898 Biochemical and Biophysical Research Communications 2012 7 Pages PDF
Abstract
► Ischemia-induced apoptosis is accompanied by ATP release from endothelial cells. ► Inhibition of ATP breakdown reduces ischemia-induced endothelial cell apoptosis. ► Protective effects of extracellular ATP seem to be mediated by P2Y-receptors. ► Reduction of ischemia-induced apoptosis is due to MEK/ERK- and PI3K/Akt-signaling.
Keywords
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Extracellular ATP attenuates ischemia-induced caspase-3 cleavage in human endothelial cells
Authors
, , , , , , ,