| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760900 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠The mTOR signaling pathway is hyperactive within the normal renal glomerulus. ⺠Immunofluoresence staining identifies intense pmTOR expression selectively within podocytes. ⺠Targeting mTOR activity with rapamycin in vivo reduces mTOR signaling and local VEGF expression. ⺠Constitutive mTOR-induced responses in podocytes likely mediate glomerular homeostasis.
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Authors
Gearoid M. McMahon, Dipak Datta, Sarah Bruneau, Martin Kann, Myda Khalid, Jacqueline Ho, Tatsuichiro Seto, Jordan A. Kreidberg, Isaac E. Stillman, David M. Briscoe,