| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760910 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Protease (PR) of XMR virus (XMRV) was successfully synthesized with cell-free system. ⺠Interface of XMRV PR with an inhibitor, amprenavir (APV), was identified with NMR. ⺠Structural heterogeneity is induced for two PR protomers in the APV:PR = 1:2 complex. ⺠Structural heterogeneity is transmitted even to distant regions from the interface. ⺠Long-range transmission of structural change may be utilized for drug discovery.
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Authors
Ayako Furukawa, Hideyasu Okamura, Ryo Morishita, Satoko Matsunaga, Naohiro Kobayashi, Takahisa Ikegami, Tsutomu Kodaki, Akifumi Takaori-Kondo, Akihide Ryo, Takashi Nagata, Masato Katahira,