| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10760982 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠Mice lacking the scaffolding protein GIT2 (GIT2â/â mice) have decreased bone mass. ⺠GIT2â/â mice exhibit a decrease in osteoblasts and reduced osteoblastic activity. ⺠GIT2â/â mice exhibit an increase in osteoclasts but decreased osteoclastic activity. ⺠Stem cells from GITâ/â mice have impaired differentiation into mature osteoblasts.
Keywords
ERKPAKAP2GRKDEXALPLGEFGPCRosterixQCTBMDGITDPDMSCFAKdeoxypyridinolineGPCR kinaseRUNX2c-SrcPIXGIT2col1aBV/TVAdipogenesisOsteoblastOsteoblastogenesisTrabecular boneOsteoclastOsxCSABone mineral densitydual-energy X-ray absorptiometrystandard error of the meanCOOLcross sectional areaMesenchymal stem cellextracellular-signal regulated kinaseRunt-related transcription factor 2guanine nucleotide exchange factorPKLLipoprotein lipaseMEKSEMwild typeCytoskeletonp21-activated kinasefocal adhesion kinaseG protein-coupled receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Xiaojuan Wang, Shaoxi Liao, Erik R. Nelson, Robert Schmalzigaug, Robert F. Spurney, Farshid Guilak, Richard T. Premont, Diane Gesty-Palmer,