| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10761008 | Biochemical and Biophysical Research Communications | 2012 | 6 Pages |
Abstract
⺠cAMP-induced c-fos expression in hippocampal neurons requires a submembraneous Ca2+ pool. ⺠The submembraneous Ca2+ pool derives from intracellular ER stores. ⺠Expression of IP3-metabolizing enzymes inhibits cAMP-induced c-fos expression. ⺠SRE-mediated and CRE-mediated gene expression is sensitive to IP3-metabolizing enzymes. ⺠Intracellular Ca2+ release is required for cAMP-induced nuclear translocation of TORC1.
Keywords
NMDAinositol 1,4,5 triphosphatesarcoplasmic/endoplasmic reticulum Ca2+-ATPaseTORCSREc-fosN-methyl-d-aspartateCREBIP3ERKCREcAMPMAPKadenylyl cyclaseBAPTA-AMTranscriptioncAMP response elementSerum response elementSERCAHippocampal neuronscAMP response element binding proteinmitogen-activated protein kinaseextracellular signal-regulated kinase
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Wenting Zhang, Asmita Tingare, David Chi-Heng Ng, Hong W. Johnson, Michael J. Schell, Rebecca L. Lord, Sangeeta Chawla,